The School main campus is located at Ogbomoso North Local Government, Ogbomoso, Oyo State, Nigeria with geographical coordinates 8° 8' 0" North, 4° 16' 0" East. This is where most of the university's teaching and research is carried out. The Ogbomoso Campus also houses the central administration of the university. The Ogbomoso Campus has five faculties and the Post-graduate school where courses are taught in various fields of pure and applied science, medicine, agriculture, engineering and technology, and environmental science. The main campus first gate is located along the Old Ogbomosho-Ilorin road.
The second entrance is referred to as LAUTECH second gate, also known as Under G gate, which leads to Under-G, Nurudeen, Stadium, Kuye, and more.
The College of Health Sciences campus, once located in Osogbo, Osun state, Nigeria, has been relocated to along Old Ogbomoso-Ilorin Road, Ogbomoso, Oyo state. There are four faculties in the College of Health Sciences: basic medical sciences, basic clinical sciences, clinical sciences, and nursing sciences.
On Wednesday 31 May 2023, Governor Seyi Makinde of Oyo state granted authorization for the designation of Prof. Olawale Olakulehin as the interim Chief Medical Director (CMD) of LAUTECH Teaching Hospital in Ogbomoso. He also appointed the principal officer and another appointment in the college. The announcement was made known by the Chief of staff to the governor.
The Iseyin Campus is located in Iseyin, Oyo state, Nigeria. The campus, headed by a Provost, houses the College of Agricultural Sciences and Renewable Natural Resources, Iseyin Campus, which consists of the Faculty of Renewable Natural Resources and Faculty of Agricultural Sciences. On 15 September, 38 kilometers of Oyo-Iseyin Road leading to the new campus were commissioned for easy access.
As of 10 October 2023, 1,533 students resumed in the Iseyin campus as earlier announced by Governor Seyi Makinde. All departments of Agriculture and Biotechnology were moved to the new campus in Iseyin. The provost stated that the second semester will commence officially on 23 October 2023.
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